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Lost Season 5 is set to air air on Wednesday, February 4th 2009! Season 5 will have 17 episodes.
Considering the fact that the island was momentarily discovered by men working for Penny in Season 3 finale, I guess The Looking Glass Station will also play a role in Season 5!
According to Season 5 Spoilers from Lostpedia-
Season 5 is about why the people in the outside world need to get back [to the Island]